Ex vivo gene therapy for treatment of CLN2 Batten disease using a canine model. We are pursuing combined treatment of the brain and retina to achieve amelioration of all neurologic symptoms in this disease
There is evidence that redox active metals such as copper contribute to Alzheimer’s disease. We are interested in characterizing how changes in metal ion homeostasis contribute to Alzheimer’s disease with an emphasis on inflammation.
The focus of my current research is on development of therapies for neurodegenerative disorders, with particular emphasis on the hereditary neuronal ceroid-lipofusconoses (NCLs) and amyotrophic lateral sclerosis (ALS).
Dr. Hu Huang’s primary focus involves the study of the retina (a metabolically active tissue that senses light). Dysregulation of metabolism results in retinal cell dysfunction and miscommunication, subsequent cell death and vision loss.